军事医学2011，Vol.35Issue(9)：663-665,680,4.
睡眠剥夺应激对大鼠海马的损伤作用及其对探究行为的影响
Adverse effect of sleep deprivation on hippocampus and exploratory behavior in rats
摘要
Abstract
Objective To observe the effect of sleep deprivation on hippocampus and exploratory behavior in rats. Methods The modified multiple platform method( MMPM ) was used to establish sleep deprivation model. Open-field test was applied to evaluate the behavior of the model rats. Results The sleep deprivation rats showed decreased body massin the 3rd, 5th and 7th day compared with the control groups. The glucocorticoid( GC ) content and lactate dehydrogenase ( LDH ) activity in the plasma of the sleep deprivation rats showed a significant reduction from 5th to 7th day compared with the control groups. The neuron specific enolase( NSE ) content in the plasma was reduced significantly in sleep deprivation rats compared with the control groups. Hematoxylin and eosin stain of tissue slice showed that sleep deprivation could induce injury to hippocampus in rats. The exploratory behavior of the sleep deprivation rats decreased significantly compared with the control groups. Conclusion Sleep deprivation can suppress the increase in body mass of rats and cause hippocampus injury. With the increase in the sleep deprivation time, the exploratory behavior of the sleep deprivation rats is gradually suppressed.关键词
睡眠剥夺/海马损伤/探究行为Key words
sleep deprivation/hippocampus injury/exploratory behavior分类
医药卫生引用本文复制引用
王新兴,梅竹松,刘伟丽,张志清,武磊,弓景波,钱令嘉..睡眠剥夺应激对大鼠海马的损伤作用及其对探究行为的影响[J].军事医学,2011,35(9):663-665,680,4.基金项目
国家科技重大专项 (2008ZXJ090-011) （2008ZXJ090-011）
国家自然科学基金青年项目(81000584) （81000584）
