军事医学2011，Vol.35Issue(9)：666-671,6.
睡眠剥夺影响脑执行功能的心理生理研究
Psychological and physiological impact of 36 h total sleep deprivation on the executive function of the brain
摘要
Abstract
Objective To study the impact of 36 h total sleep deprivation( TSD ) on the executive control function of the brain. Methods Healthy young men ( n = 14 ) undergoing the visual Go/Nogo task before and after 36 h sleep deprivation were studied with event related potentials ( ERP ) and functional magnetic resonance imaging ( fMRI ). Results The hit rate of Go/Nogo task decreased and the false alarm rate increased after 36 h sleep deprivation. TSD induced decreased the amplitude, but enhanced the latency of Nogo-N2 and Nogo-P3 on Fz and Nogo-P3 on Cz electrode. The latency of the recovery value of Nogo-N2 and Nogo-P3 was statistically significant compared to the baseline. TSD-induced positive and negative blood oxygenation level-dependent ( BOLD ) signals were compared with those after a normal night's sleep ( NORM ). The activated areas with positive BOLD signals included the superior prefrontal cortex and inferior prefrontal cortex while those with negative BOLD signal were in the anterior cingulate cortex ( ACC ) and right lingual gyrus. Conclusion The executive control function of the brain is decreased after 36 h TSD. The increased activation of PFC might be related to the compensatory response since more attention resources are needed to perform the Go/Nogo task after 36 h TSD. The recovery sleep can effectively regain the impacted executive function.关键词
睡眠剥夺/脑执行功能/事件相关电位/功能性磁共振成像Key words
sleep deprivation/executive brain function/ERP/functional MRI分类
医药卫生引用本文复制引用
邵永聪,叶恩茂,王富贵,毕国华,靳霄,杨征..睡眠剥夺影响脑执行功能的心理生理研究[J].军事医学,2011,35(9):666-671,6.基金项目
军队"十一五"重点指令性课题 (06Z066) （06Z066）
