中山大学学报（医学科学版）2011，Vol.32Issue(4)：505-510,6.
多囊卵巢综合征及不同受孕方式对妊娠结局的影响
Influence of Polycystic Ovary Syndrome and Different Ways to Conceive on Pregnancy Outcomes
摘要
Abstract
[Objective] To investigate the pregnant outcomes of women with polycystic ovary syndrome (PCOS) and the effects oi different conceived ways on it. [Methods] A total of 220 pregnant women with PCOS in Sun Yat-sen Memorial Hospital (SYSM) of Sun Yat-sen University between January 2007 and December 2010 were collected, 11778 pregnant women without PCOS at the same period as the control. The pregnant complication, pregnant outcome, as well as the various conceived ways including natural conception, ovulation and in vitro fertilization-embryo transfer (FVF-ET) were compared. [Results] The incidences of spontaneous abortion, abnormal glucose metabolism, hypertensive disorders in pregnancy, premature delivery, twins, fetal growth restriction (FGR) and neonatal jaundice were higher in PCOS group than that in control group (P<0.05), which were 34.54% vs 8.86%, 49.31% vs 8.22% , 10.42% vs 2.17% , 18.75% vs 10.13% , 22.92% vs 4.26% , 7.64% vs 2.11% and 17.36% vs 8.95% , respectively. Besides, the incidence of macrosomia (4.17% vs 2.46%), fetal malformation (2.08% vs 2.52%), and neonatal asphyxia (10.42% vs 7.84%) in PCOS group were also increased, compared to the control group, although there were no statistically significance.In terms of the effects of conceived ways on pregnant outcomes,compared to the PCOS patients in natural conception,the incidence of having twins (45.24% vs 2.90%) and FGR (11.90% % vs 1.45%) of PCOS patients conceived by IVF-ET increased; those in patients taking ovulation showed the same trend, whose incidences of twins and FGR were 36.36% and 15.15%, respectively. The preterm birth rate of IVF- ET, ovulation group and natural conception group were 26.19%, 21.21%, and 10.14%, respectively. The difference was statistically significant among these three groups. No significant differences were showed on the incidences of the other complications. [Conclusions] Incidences of pregnant outcomes including spontaneous abortion, abnormal glucose metabolism, hypertensive disorders in pregnancy, preterm labor, twins, fetal growth restriction and neonatal jaundice, but not macrosomia, fetal malformation and asphyxia, significantly increased among women with PCOS. The conceived ways of PCOS patients play a role on the incidence of twins, FGR, and preterm delivery.关键词
多囊卵巢综合征；妊娠结局；受孕方式Key words
polvcystic ovarv syndrome/pregnancy outcome/conceived way分类
医药卫生引用本文复制引用
王蕴慧,赵会丹,刘玉昆,曾梅,张建平,杨冬梓..多囊卵巢综合征及不同受孕方式对妊娠结局的影响[J].中山大学学报（医学科学版）,2011,32(4):505-510,6.基金项目
广东省科技计划项目(2009B030801157) （2009B030801157）
