重庆理工大学学报（自然科学版）2011，Vol.25Issue(5)：35-41,7.
多肽定量构效关系建模方法
Research on Modeling Method of Quantitative Structure-activity Relationship for Peptides
摘要
Abstract
Quantitative structure-activity relationship ( QSAR) of the design of drugs and peptides plays a critical role. This paper listed three sorts of the peptides such as bitter tasting peptide, agioten-sin-converting enzyme inhibitor and bactericidal peptides,and those were always used to QSAR modeling systems. The paper briefly introduced several QSAR modeling methods in common use, such as multivariate linear regression analysis ( MLR ) , partial lease squares ( PLS) , support vector machine ( SVM ) , principal component analysis ( PCA), stepwise linear regression ( SLR ) and artificial neural network (ANN). Valuable reference is offered to QSAR of peptides research for selecting calculation modeling method.关键词
多肽/定量构效关系/常用体系Key words
peptides/ quantitative structure-activity relationship/ common systems分类
生物科学引用本文复制引用
张娅,丁元,王远强,王伯初..多肽定量构效关系建模方法[J].重庆理工大学学报（自然科学版）,2011,25(5):35-41,7.基金项目
重庆市自然科学基金资助项目(CSTC,2010BB5306) （CSTC,2010BB5306）
