中德临床肿瘤学杂志（英文版）2011，Vol.10Issue(10)：570-574,5.DOI:10.1007/s10330-011-0859-7
循环脂联素:肝细胞癌的一种潜在预后指标
Circulating adiponectin: a potential prognostic marker for hepatocellular carcinoma
Mohamed E. E. Shams 1Mohammed M. H. Al-Gayyar 2Enaase A. M. E. Barakat 3Mohamed A. Ebrahim 3Mamdouh M. El-Shishtawy2
作者信息
- 1. Department of Pharmaceutics, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt
- 2. Department of Biochemistry, Faculty of Pharmacy, University of Mansoura, Mansoura, Egypt
- 3. Department of Internal Medicine, Faculty of Medicine, University of Mansoura, Mansoura, Egypt
- 折叠
摘要
Abstract
Objective: We planned this study to investigate the relation between serum adiponectin level and hepatocel-lular carcinoma (HCC): risk, features and prognosis. Methods: The study included 100 patients with HCC and 40 healthy control subjects. Adiponectin levels were determined by an enzyme-linked immunosorbent assay kit. Results: In the subset of patients with compensated cirrhosis, the mean serum adiponectin level was significantly lower in HCC cases compared to healthy controls (88.6 versus 115 ng/mL; P = 0.012). In addition, serum adiponectin levels correlated negatively with tumor size (P = 0.004) and were significantly lower in patients with vascular invasion and distant metastases (P = 0.03 and P = 0.02 respectively). Furthermore, the median overall survival was significantly higher in the high adiponectin group than the low adiponectin group (median 12.5 versus 9.5 months; log rank = 4.6, P = 0.03). Conclusion: Decreased circulating adiponectin level may play a role in the development of HCC and is a potential poor prognostic marker. These data should be validated in further prospective studies. Also the mechanisms by which adiponectin affect the course of HCC need to be clarified.关键词
adiponectin/ hepatocellular carcinoma (HCC)/ prognostic markerKey words
adiponectin/ hepatocellular carcinoma (HCC)/ prognostic marker引用本文复制引用
Mohamed E. E. Shams,Mohammed M. H. Al-Gayyar,Enaase A. M. E. Barakat,Mohamed A. Ebrahim,Mamdouh M. El-Shishtawy..循环脂联素:肝细胞癌的一种潜在预后指标[J].中德临床肿瘤学杂志（英文版）,2011,10(10):570-574,5.
