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三株鸡马立克氏病病毒流行毒株基因组重复区的序列测定及分析

许娜娜 刘长军 张艳萍 李志杰 侯广玉 张锋 丛锋 杨文闯 成云

中国兽医科学2011,Vol.41Issue(7):666-671,6.
中国兽医科学2011,Vol.41Issue(7):666-671,6.

三株鸡马立克氏病病毒流行毒株基因组重复区的序列测定及分析

Sequencing and analysis of genomic repeat regions of three isolates of Marek's disease virus

许娜娜 1刘长军 1张艳萍 1李志杰 1侯广玉 1张锋 1丛锋 1杨文闯 1成云1

作者信息

  • 1. 中国农业科学院哈尔滨兽医研究所兽医生物技术国家重点实验室禽传染病研究室,黑龙江哈尔滨150001
  • 折叠

摘要

Abstract

Genomic repeat regions of three Marek's disease virus(MDV) isolates in domestic were sequenced and analyzed.Comparing with the sequences available in GenBank,these strains belonged to an independent phylogenetic branch,and there was a high sequence homology among them.The long repeat regions of these strains,genome were about 12 kb in length with 43,40,43 predicted open reading frames(ORFs),respectively,and the short repeat regions were about 12 kb in length with 27,25,26 predicted ORFs,respectively.The unique and common amino acid mutations were occurred in some ORFs of these strains,which was the unique genetic characteristics of MDV-1 strains in domestic.The study will provide the research materials for the prevalence,genetic variation,protection and control of MDV in domestic.

关键词

马立克氏病病毒/基因组重复区/序列分析/致病性

Key words

Marek's disease virus/genomic repeat regions/sequence analysis/pathogenicity

分类

农业科技

引用本文复制引用

许娜娜,刘长军,张艳萍,李志杰,侯广玉,张锋,丛锋,杨文闯,成云..三株鸡马立克氏病病毒流行毒株基因组重复区的序列测定及分析[J].中国兽医科学,2011,41(7):666-671,6.

基金项目

国家重点实验室基本科研业务费专项(SKLVBP201008) ()

中央级公益性科研院所基本科研业务费专项(ZGKJ201102) ()

中国兽医科学

OA北大核心CSCDCSTPCD

1673-4696

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