临床神经外科杂志2011，Vol.8Issue(4)：187-189,3.DOI:10.3969/j.issn.1672-7770.2011.04.007
胶质瘤中P53、EGFR、Ki-67及MGMT 的表达及临床意义
Expression and clinical significance of P53,EGFR,Ki-67 and MGMT in glioma
摘要
Abstract
Objective To investigate the expression and clinical significance of P53 , EGFR, Ki67 and MGMT in different grade gliomas. Methods The expressions of P53 , Ki-67 , EGFR and MGMT proteins in different grade gliomas were assayed by immunohistochemistry and expression differences were analyzed statistically. Results The positive rates of P53 were 71. 4％ ,73. 1％ and 60.0％ in grade Ⅱ ～ Ⅳ. EGFR protein is positive in 95 cases, its positive expression rate and staining intensity were positively correlated with the pathological grade ( P ＜ 0. 01 ) . Ki-67 express in all different grades of glioma and the expression level was increased grade (P ＜ 0. 01). MGMT expressions is positive in 84 cases and negative in 68. The expression did not correlate with grade ( P＞0.05). Conclusions The expression of' EGFR and Ki-67 are significantly correlate with the WHO classification of glioma, EGFR and Ki-67 are significantly associated with malignant progression and poor prognosis. P53 and MGMT have no correlation with grades of glioma. Detection can help to assess the ability of invasion, proliferation, prediction of glioma to radiotherapy and chemotherapy sensitivity and to determine the effectiveness of molecular targeted therapy.关键词
胶质瘤/免疫组化/病理Key words
glioma/ immunohistochemistry / pathology分类
医药卫生引用本文复制引用
胡新华,张锐,马骏,陈永严,张岩松,邹元杰,章文斌,苗伟,刘宏毅..胶质瘤中P53、EGFR、Ki-67及MGMT 的表达及临床意义[J].临床神经外科杂志,2011,8(4):187-189,3.基金项目
南京市医学科技发展资金资助项目(ZKX10021) （ZKX10021）
