首页|期刊导航|中华医学杂志（英文版）|Impact of smoking status and pathologic type on epidermal growth factor receptor mutations in lung cancer
中华医学杂志（英文版）2011，Vol.124Issue(16)：2457-2460,4.DOI:10.3760/cma.j.issn.0366-6999.2011.16.011
Impact of smoking status and pathologic type on epidermal growth factor receptor mutations in lung cancer
Impact of smoking status and pathologic type on epidermal growth factor receptor mutations in lung cancer
摘要
Abstract
Background Epidermal growth factor receptor (EGFR) mutations in lung carcinomas can make the disease more responsive to the treatment with tyrosine kinase inhibitors. We aimed to evaluate the prevalence of EGFR mutations in a large series of lung carcinomas.Methods We examined 1195 consecutive lung cancer patients for EGFR mutations in exons 18, 19, and 21 using direct sequencing of polymerase chain reaction products. A detailed smoking history was obtained. Patients were categorized as never smokers (＜100 lifetime cigarettes), former smokers (quit ＞1 year ago), or current smokers (quit ＜1 year ago).Results There were EGFR mutations in 9 (4.5%) of 201 squamous carcinomas, in 1 (2%) of 50 large cell carcinomas,and in 1 (2.3%) of 44 small cell carcinomas that were investigated. Three hundred and twenty-seven mutations were found in the series of 858 adenocarcinomas (38.1%). Among 858 lung adenocarcinomas, we detected EGFR mutations in 250 (48.6%) of 514 never smokers, 39 (33.9%) of 115 former smokers, and 38 (16.6%) of 229 current smokers.Significantly fewer EGFR mutations were found in people who smoked for more than 15 pack-years (P=0.0002) or stopped smoking less than 15 years ago (P=0.033) compared with individuals who never smoked.Conclusions Adenocarcinoma is the most frequent EGFR mutation pathologic type in lung cancer. The likelihood of EGFR mutations in exons 18, 19 and 21 decreases as the number of pack-years increases. Mutations were less common in people who smoked for more than 15 pack-years or who stopped smoking cigarettes less than 15 years ago. These data can assist clinicians in assessing the likelihood of exons 18, 19, or 21 EGFR mutations in Chinese patients with lung cancer when mutational analysis is not feasible.关键词
lung neoplasms/smoking/pathologic type/receptor, epidermal growth factor/mutationKey words
lung neoplasms/smoking/pathologic type/receptor, epidermal growth factor/mutation引用本文复制引用
HUANG Yi-sheng,WU Yi-long,YANG Jin-ji,ZHANG Xu-chao,YANG Xue-ning,HUANG Yu-juan,XU Chong-rui,ZHOU Qing,WANG Zhen,SU Jian..Impact of smoking status and pathologic type on epidermal growth factor receptor mutations in lung cancer[J].中华医学杂志（英文版）,2011,124(16):2457-2460,4.基金项目
This study was supported by the grants from Science and Technology Pojects of Guangdong Province (No.2010B031500031),Science and Technology Pojects of Guangzhou (No.2010Y1-C931),and Clinical Medicine Scientific Research Foundation of WU Jie-ping (No.320.6700.09043). （No.2010B031500031）
