首页|期刊导航|中华医学杂志（英文版）|Relationship of left heart size and left ventricular mass with exercise capacity in chronic heart failure
中华医学杂志（英文版）2011，Vol.124Issue(16)：2485-2489,5.DOI:10.3760/cma.j.issn.0366-6999.2011.16.016
Relationship of left heart size and left ventricular mass with exercise capacity in chronic heart failure
Relationship of left heart size and left ventricular mass with exercise capacity in chronic heart failure
摘要
Abstract
Background Impaired exercise capacity is one of the most common clinical manifestations in patients with chronic heart failure (CHF). The severity of reduced exercise capacity is an indicator of disease prognosis. The aim of the current study was to investigate the association between left heart size and mass with exercise capacity.Methods A total of 74 patients were enrolled in the study, with 37 having congestive heart failure (left ventricular ejection fraction (LVEF) ＜0.45) and the other 37 with coronary heart disease (by coronary angiography) serving as the control group (LVEF ＞0.55). Echocardiography and cardiopulmonary exercise test were performed. The multiply linear regression model was used to evaluate the association between echocardiogrphic indices and exercise capacities.Results The study showed that left ventricular end diastolic / systolic diameter (LVEDD/LVESD), left atrial diameter (LAD) and left ventricular mass index (LVMI) were significantly enlarged in patients with chronic heart failure compared with controls (P ＜0.01). The VO2AT, Peak VO2, Load AT, and Load Peak in chronic heart failure patients were also significantly reduced compared with controls (P ＜0.05), VE/VCO2 slope was increased in patients with chronic heart failure (P ＜0.01). Multivariate linear regression analysis indicated that the patients' exercise capacity was significantly associated with the left heart size and mass, however, the direction and/or strength of the associations sometimes varied in chronic heart failure patients and controls. Load AT correlated negatively with LVEDD in chronic heart failure patients (P=0.012), while Load AT correlated positively with LVEDD in control patients (P=0.006). VE/VCO2 slope correlated positively with LAD (B=0.477, P ＜0.0001) in chronic heart failure patients, while the VE/VCO2 slope correlated negatively with LAD in control patients (P=0.009).Conclusion The study indicates that the size of LVEDD and LAD are important determinants of exercise capacity in patients with CHF, which may be helpful to identify exercise tolerance for rourine monitoring of systolic heart failure.关键词
echocardiography/exercise tolerance/exercise test/heart failure/systolicKey words
echocardiography/exercise tolerance/exercise test/heart failure/systolic引用本文复制引用
SHEN Yu-qin,WANG Le-min,CHE Lin,SONG Hao-ming,ZHANG Qi-ping..Relationship of left heart size and left ventricular mass with exercise capacity in chronic heart failure[J].中华医学杂志（英文版）,2011,124(16):2485-2489,5.基金项目
This work was supported by a grant from the Shanghai Science and Technology Commission of China (No.05DZ19505). （No.05DZ19505）
