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Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme

LI Wen-bin TANG Kai ZHANG Wei YAN Wei YOU Gang LI Shao-wu ZHANG Long HUANG Yan-jie JIANG Tao

中华医学杂志（英文版）2011，Vol.124Issue(17)：2589-2592,4.

中华医学杂志（英文版）2011，Vol.124Issue(17)：2589-2592,4.DOI:10.3760/cma.j.issn.0366-6999.2011.17.005

Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme

LI Wen-bin ¹TANG Kai ²ZHANG Wei ¹YAN Wei ¹YOU Gang ¹LI Shao-wu ¹ZHANG Long ³HUANG Yan-jie ⁴JIANG Tao⁴

作者信息

1. Department of Neurosurgery Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China
2. Cancer Center,Beijing Shijitan Hospital,Capital Medical University,Beijing 100038,China
3. Department of Radiology Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China
4. College of Public Health,Peking University,Beijing 100083,China
折叠

摘要

Abstract

Background Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults.Magnetic resonance imaging (MRI) is routinely used in the diagnosis,characterization and clinical management of GBM.The diagnosis and treatment of GBM is largely guided by histopathology and immunohistochemistry.This study aimed to identify the relationship between magnetic resonance features and molecular pathology of GBM.Methods MRI images of 43 glioblastoma patients were collected.Four imaging features,degree of edema,contrast tumor enhanced/T2 ratio,multiple lesions and tumor across the midline,were selected to identify their relationship with P53,Ki-67 and O6-methylguanine-DNA methltransferase (MGMT) expression in patients with GBM.The relationship between imaging features and molecular pathology was studied by chi-square test using the software SPSS 13.0.Results High expression of P53 was found correlated with low contrast tumor enhanced/T2 ratio,low expression of Ki-67 was correlated with multiple lesions and high expression of KI-67 may be related with tumor across the midline,low expression of MGMT was correlated with edema.Conclusion Some MRI features such as the degree of edema,contrast tumor enhanced/T2 ratio,multiple lesions and tumor acrossing the midline are correlated with P53,Ki-67 and MGMT of GBM.

关键词

glioblastoma multiforme/magnetic resonance imaging/molecular pathology

Key words

glioblastoma multiforme/magnetic resonance imaging/molecular pathology

引用本文复制引用

LI Wen-bin,TANG Kai,ZHANG Wei,YAN Wei,YOU Gang,LI Shao-wu,ZHANG Long,HUANG Yan-jie,JIANG Tao..Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme[J].中华医学杂志（英文版）,2011,124(17):2589-2592,4.

基金项目

This work was supported by grants from Chinese National Key Project of Science and Technology Supporting Programs (No.2007BAI05B08),and the National Natural Science Foundation of China (No.30772238). （No.2007BAI05B08）

中华医学杂志（英文版）

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ISSN：0366-6999

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