中华医学杂志（英文版）2011，Vol.124Issue(16)：2559-2560,2.DOI:10.3760/cma.j.issn.0366-6999.2011.16.029
Docetaxel-induced nail toxicity: a case of severe onycholysis and topic review
Docetaxel-induced nail toxicity: a case of severe onycholysis and topic review
Chi-pan Lau 1Pun Hui 2Tak-cheung Chan3
作者信息
- 1. Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong
- 2. State Key Laboratory in Oncology in South China
- 3. Sir Y. K. Pao Centre for Cancer, Hong Kong, China
- 折叠
摘要
Abstract
Docetaxel is a commonly-used anti-cancer chemotherapeutic agent given its efficacy in a large varlety of solid tumors. It is associated with various adverse effects one of which is nail toxicity. We report a case of severe onycholysis as a result of treatment with docetaxel in a patient who suffered from metastatic nasopharyngeal carcinoma. The case report will be followed by a discussion on the possible mechanism and preventive strategies for taxane-induced nail toxicity.Taxane including both paclitaxel and docetaxel has been used extensively in the past decade for the treatment of many types of solid malignancies. It is associated with specific adverse effects including neuropathy, myalgia as well as higher incidence of allergic reaction. Nail toxicity is a relatively common adverse effect of taxane that can be easily neglected by oncologists whose primary focus is tumor response to therapy. We report a case of severe nail toxicity as a result of docetaxel treatment in a patient who suffered from metastatic nasopharyngeal carcinoma.关键词
Docetaxel/onycholysis/nail toxicityKey words
Docetaxel/onycholysis/nail toxicity引用本文复制引用
Chi-pan Lau,Pun Hui,Tak-cheung Chan..Docetaxel-induced nail toxicity: a case of severe onycholysis and topic review[J].中华医学杂志（英文版）,2011,124(16):2559-2560,2.
