临床与实验病理学杂志2011，Vol.27Issue(8)：835-837,3.
淋巴细胞性乳腺病的临床病理分析
Clinicopathologic features of lymphocytic mastopathy
吴萍 1何妙侠 2朱焱 2白辰光 2郑唯强2
作者信息
- 1. 江苏省淮安市妇幼保健院病理科,淮安,223002
- 2. 第二军医大学长海医院病理科,上海,200433
- 折叠
摘要
Abstract
Purpose To elucidate the clinicopathologic features and differential diagnosis of lymphocytic mastopathy ( LM ). Methods The clinical and pathological characteristics were observed in 3 cases of LM. Immunohistochemical staining of CD3 , CD19 and CD20 using EnVision method as well as gene rearrangement analysis were performed. Results A 56-year-old male and two ( 48- and 36-year-old, respectively ) female patients without any family history or diabetes mellitus were enrolled in this study. All the specimens contained a distinct and palpable firm mass. The cut surface revealed a white to pale grey mass indistinguishable from the surrounding tissue. Microscopically, the distinct atrophy, even disappearance of lobules with plenty of lymphocytic infiltrates were disclosed. An exuberant periductal, perilobular and perivascular lymphocytic infiltrates were identified. Immunohistochemical results showed that the infiltrated lymphocytes were homogeneously positive for CD3 , CD19 and CD20. Gene rearrangement of IGH and TCR revealed germline configuration. Conclusions LM is a relatively rare entity. It does not appear to be a B cell neoplasm though predominate lymphocytes are found surrounding the lobules or ducts. The combination of immunohistochemisry with gene rearrangement analysis is helpful to warrant distinction from other breast lesions.关键词
乳腺疾病/淋巴细胞性/诊断Key words
breast diseases/ lymphocytic/ diagnosis分类
医药卫生引用本文复制引用
吴萍,何妙侠,朱焱,白辰光,郑唯强..淋巴细胞性乳腺病的临床病理分析[J].临床与实验病理学杂志,2011,27(8):835-837,3.
