现代检验医学杂志2011，Vol.26Issue(4)：132-134,3.DOI:10.3969/j.issn.1671-7414.2011.04.048
107例多发性骨髓瘤M蛋白检测与免疫学分型分析
M Protein Detection and Immunology Typing Analysis of 107 Patients with Multiple Myeloma
刘玉梅 1赵有利 1石翀 1李光迪1
作者信息
- 1. 兰州大学第二医院检验科,兰州,730030
- 折叠
摘要
Abstract
Objective To study the application of immunofixation electrophoresis (IFE) in typing M proteins. Methods Serum M proteins were detected in 107 patients by serum protein electrophoresis and IFE. Results Among 107 patients with MM,96 of them were affirmed to had M band with serum protein electrophoresis but M bands appeared in all of the MM patients with IFE. IFE manifest :there were IgG 63 cases (IgG κ 29 and IgG λ 34),IgA 25 cases (IgA κ 11 and IgA λ 14),IgM 3 cases (IgM κ 1 and IgM λ 2) and free light chain 15 cases (κ 2 and λ 13). Of 60 cases of MM,39 patients were detected to had Benee Jones proteins (12 κ and 27λ) in urine by IFE. The serum IFE had the highest sensitivity in identification M protein among the three methods. The second was serum protein electrophoresis and the lowest was the urine Bence Jones proteins (P ＜ 0.01). Conclusion The technology of IFE, characterized by easy differentiation of electrophoretic bands,simple operation, high sensitivity and rapidity ,has great value in typing M proteins.关键词
多发性骨髓瘤/M蛋白/血清蛋白电泳/免疫固定电泳/本周氏蛋白Key words
multiple myeloma / M protein / serum protein electrophoresis / immunofixation electrophoresis / Bence Jones protein分类
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刘玉梅,赵有利,石翀,李光迪..107例多发性骨髓瘤M蛋白检测与免疫学分型分析[J].现代检验医学杂志,2011,26(4):132-134,3.
