基础医学与临床2011，Vol.31Issue(9)：1060-1063,4.
低密度脂蛋白受体相关蛋白5与骨量相关性的研究进展
Research progress of low-density lipoprotein receptor-related protein 5
摘要
Abstract
Bone mass is affected by multiple genetic and environmental factors, genetic factors contribute to more than 60％ of the variance in bone mineral density (BMD). Recently, researches suggested that low-density lipoprotein receptor-related protein 5 (LRP5) was closely related to differentiation of osteoblasts, BMD and/or osteoporotic fracture. The regulation mechanisms of bone mass which LRP5 involved in provide new insights into treat esteoporosis, and specific agonists or antagonists in these pathways could be potential targets for new anti-osteoporosis drags.关键词
低密度脂蛋白受体相关蛋白5/骨量/成骨细胞Key words
low-density lipoprotein receptor-related protein 5 ( LRP5 )/ bone mass/ osteoblast分类
医药卫生引用本文复制引用
刘海娟,李梅,邢小平..低密度脂蛋白受体相关蛋白5与骨量相关性的研究进展[J].基础医学与临床,2011,31(9):1060-1063,4.基金项目
国家自然科学基金科学部主任基金(30440074) （30440074）
国家科技支撑计划项目(2008BA158802) （2008BA158802）
