临床神经病学杂志2011，Vol.24Issue(4)：261-263,3.
单胺氧化酶B基因13内含子G/A多态性与帕金森病的关系
Relationship between polymorphism of monoamine oxidase B gene intron 13 G/A and Parkinson disease
摘要
Abstract
Objective To explore the relationship between the polymorphism of monoamine oxidase B( MAOB) gene intron 13 G/A and Parkinson disease (PD). Methods PCR-Restriction Fragment Length Polymorphism (RFLP) was used to detected the MAO-B gene intron 13 G/A genotype and allele in 166 PD patients ( PD earlyonset 52 cases, late-onset 114 cases) and 170 normal controls, and the distribution was compared. Results The frequenics of mild genotype (AA), heterozygote genetype (AG) and mutant genotype (GG) had no statistical significant between PD group and normal control group. The frequencies of genotype AA ( 80.8％ ) and allele A (86. 5％ ) in PD early-onset subgroup were statistically higher than those in late-onset subgroup (60.5％ ,71.5％ ) and normal control group (60.6％ ,71.5％ ) ( all P ＜0. 05 ). There was no difference of genotype and allele between in PD late-onset subgroup and normal control group. Which also had no statistical significance between PD group and the control group with the same sex. Conclusions The frequencies increasing of the genotype AA and allele A of MAO-B gene intron 13 G/A are the risk factors of PD onset. The Polymorphism of MAO-B gene 13 intron G/A is related to PD, especially to the predisposition of the early-onset PD.关键词
帕金森病/单胺氧化酶B基因/多态性/遗传易感性Key words
Parkinson disease/ monoamine oxidase B/ polymorphism/ predisposition分类
医药卫生引用本文复制引用
李伟..单胺氧化酶B基因13内含子G/A多态性与帕金森病的关系[J].临床神经病学杂志,2011,24(4):261-263,3.基金项目
邢台市科技局科技计划项目(201032046) （201032046）
