临床神经病学杂志2011，Vol.24Issue(4)：285-287,3.
头孢曲松钠对大鼠脑皮质神经元氧糖剥夺损伤的保护作用及其机制
Protective effect and its mechanism of ceftriaxone on injured by rat's cerebral cortical cells oxygenglucose deprivational
摘要
Abstract
Objective To explore the protective effect and its mechanism of ceftriaxone(CTX) on cerebral cortical cells of rats injured by oxygen-glucose deprivational (OGD).Methods Cerebral cortical neurocytes of rats were cultured and divided into normal control group, OGD group and CTX pretreatment group.The OGD Models were established in OGD group and CTX pretreatment group.Cytoactive, the expression of glutamate transporter (GLT)-1mRNA, contents of brain-derived neurotrophic factor (BDNF) and interleukin (IL) -6 in the cell culture supernate in each group were assayed.Results Compared with normal control group, neural cytoactive and expression of GLT-1 mRNA were significantly decreased, BDNF and 1 IL-6 were significantly increased in OGD group and CTX pretreatment group( P ＜0.05 -0.01 ).Compared with OGD group, neural cytoactive, expression of GLT-1 mRNA and BDNF were significantly increase in CTX pretreatment groups (all P ＜0.01 ), and IL-6 level had no significantly change.Conclusion CTX pretreatment can protect cortical neurocytes from OGD injury by increasing the expression of GLT-1 and BDNF.关键词
头孢曲松钠/细胞培养/氧糖剥夺/谷氨酸转运体-1Key words
ceftriaxone/ cell culture/ oxygen-glucose deprivation/ glutamate transporter-1分类
医药卫生引用本文复制引用
刘春华,王维治..头孢曲松钠对大鼠脑皮质神经元氧糖剥夺损伤的保护作用及其机制[J].临床神经病学杂志,2011,24(4):285-287,3.基金项目
黑龙江省卫生厅基金项目(2009-110) （2009-110）
哈尔滨医科大学青年基金项目(QN2009-11) （QN2009-11）
