中国当代儿科杂志2011，Vol.13Issue(8)：631-634,4.
沙利度胺治疗幼年特发性关节炎的效果分析
Efficacy of thalidomide for treatment of juvenile idiopathic arthritis
韩彤昕 1李彩凤 1王江 1邝伟英 1周怡芳1
作者信息
- 1. 北京儿童医院风湿免疫科,北京,100045
- 折叠
摘要
Abstract
Objective To evaluate the efficacy of thalidomide in the treatment of juvenile idiopathic arthritis (JLA). Methods Twelve children with JIA who did not respond to conventional treatment were administered with thalidomide (2 mg/kg daily ). The symptoms, signs, and laboratory test results were compared before and after treatment. The thalidomide-related side effects were observed. Results The average dosage of prednisone was reduced from 1.92 ± 0.16 mg/kg · d to 0.49 ±0.42 mg/kg · d in the 12 patients 6 months after thalidomide treatment (P ＜ 0.01 ). Four patients did not need prednisone treatment any more. White blood cell count, erythrocyte sedimentation rate (ESR), C reactive protein (CRP) and serum ferritin (SF) significantly decreased after treatment in all of 12 patients (P ＜ 0. 01 ). Hemoglobin level increased to normal in 8 patients after treatment ( P ＜ 0.01 ). The number of affected joints decreased from 5 before treatment to zero to 2 after treatment in patients with polyarticular JIA ( P ＜ 0.01 ). Signs of hip involvement and Schober's sign turned negative in enthesitis-related cases. No thalidomide-related side effects were observed. Conclusions Thalidomide is effective in the treatment of JlA in children who do not respond to conventional treatment.关键词
幼年特发性关节炎/沙利度胺/儿童Key words
Juvenile idiopathic arthritis/ Thalidomide/ Child分类
医药卫生引用本文复制引用
韩彤昕,李彩凤,王江,邝伟英,周怡芳..沙利度胺治疗幼年特发性关节炎的效果分析[J].中国当代儿科杂志,2011,13(8):631-634,4.
