山东医药2011，Vol.51Issue(30)：1-3,3.
卵巢癌组织中M2型巨噬细胞密度变化及其与卵巢癌预后的关系
Prognostic value of density of M2 macrophages in human ovarian cancer
朱亚飞 1胡爱民 2张振东 1唐俊3
作者信息
- 1. 南昌大学第一附属医院,南昌,330006
- 2. 江西省肿瘤医院
- 3. 南昌大学公共卫生学院
- 折叠
摘要
Abstract
Objective To investigate the prognostic value of density of infltrating macrophages(Mp) and tumor-associated macrophages (TAMs) with M2 phenotype in human ovarian cancer. Methods Mφ were marked by CD68, and M2 were marked by CD163. Density of Mφ, M2 of 42 cases with ovarian cancer ( ovarian cancer group) and 30 cases with benign ovarian tissue ( control group) were detected by immunohistochemical staining. Mφ, M2 density, M2 and ovarian cancer cell percentage relationship between the clinical and pathological parameters were discussed. Resullts Densites of Mφ and M2 in ovarian cancer were(74.4 ±7.2)/HP and (63.8 ±8.2)/HP respectively, in contrast with ( 18.4 ±4.2)/HP and (14.4 ±3.6)/HPin benigh tumor (P＜0.01). There was a higher percentage of M2(79.2％ ±18.2％) in advanced stages( Ⅲ+ Ⅳ), compared with those (48.2％ ± 12. 1％ )in early stages( Ⅰ + Ⅱ ) ( P ＜0. 05). Furthermore,higher densites and ratio of intra-tumoral M2 were positively associated with both higher FIGO stages and lymphatic metastasis. The mean survival time for higher and lower M2 density subgroup were (42.77 ±4.35) months and (61.70 ±3.22)months with significant difference( P ＜0.01 ), (51.32 ±3.25) months and (65.78 ±4. 19) months for high and low M2 ratio subgroup ( P ＜ 0.01 ). In a survival analysis, higher ratio of M2 was associated with a worse prognosis of ovarian cancer. Conclusions There is cancer related inflammation characterized by M2-polarized tumor associated macrophages in tissues of human ovarian cancer. The ratio of M2-polarized TAMs is associated with a poor prognosis of ovarian cancer.关键词
卵巢肿瘤/卵巢癌/炎症/巨噬细胞Key words
ovarian neoplasms/ ovarian cancer/ inflammation/macrophages分类
医药卫生引用本文复制引用
朱亚飞,胡爱民,张振东,唐俊..卵巢癌组织中M2型巨噬细胞密度变化及其与卵巢癌预后的关系[J].山东医药,2011,51(30):1-3,3.
