山东医药2011，Vol.51Issue(32)：6-9,后插1,5.
溃结汤对大鼠溃疡性结肠炎治疗及肠黏膜NF-κB的影响
Effect of kuijietang on NF-κB in intestinal mucosa of rats with ulcerative colitis
摘要
Abstract
Objective To investigate the activation and expression of NF-κB and effects of anti-inflammatory treatment of traditional Chinese medical complex kuijietang ( KJT) in the intestinal mucosa of rats with ulcerative colitis ( UC).Methods Selecting 50 healthy adult Wistar rats, we induced rats model with cellular immunoreactive UC by compound method (2.4-chlorodinitrohenzene and acetic acid).Forty UC Wistar rats established were divided randomly into model group , low dose KJT group , high dose KJT group and sulphasalaine ( SASP) group, while 10 normal Wistar rats in control group.Measurement indexs included colon weight, scoring of gross morphologic damage in acute inflammation , pathologic observation of tissues with HE staining, observation of scanning electron microscope samples, and NF-κB p65 immunohistochemistry staining, which were analyzed by image analysis system.Results Compared with those in control group, colon weight, scoring of gross morphologic damage, expression of NF-κB p65 were markedly higher in model group.The abovementioned indexs in low dose KJT group , high dose KJT group and SASP group were significantly lower than those in model group.Conclusion The increased expression may be involved in the pathogenesis of UC and the inhibition of NF-κB expression may be a central part of the anti-inflammatory action of KJT and SASP.关键词
结肠炎,溃疡性/NF-κB/细胞因子/溃结汤/柳氮磺胺吡啶Key words
colitis, ulcerative/ nuclear factor kappa B/ cytokine/ kuijietang/ sulfasalazine分类
医药卫生引用本文复制引用
聂红峰,张萍,赵发,张燕..溃结汤对大鼠溃疡性结肠炎治疗及肠黏膜NF-κB的影响[J].山东医药,2011,51(32):6-9,后插1,5.基金项目
河北省卫生厅科技攻关计划(062761329). （062761329）
