重庆医学2011，Vol.40Issue(27)：2751-2753,3.DOI:10.3969/j.issn.1671-8348.2011.27.022
帕利哌酮和奥氮平治疗精神分裂症急性期的对照研究
Comparative study for treatment with Paliperidone release tablets and Olanzapine in schizophrenia
苏华龙 1符巍 1李大齐 1李清均 1陈俊杉1
作者信息
摘要
Abstract
Objective To compare the efficacy and side effects of Paliperidone release tablets and Olanzapine in treating acute schizophrenia. Methods 68 patients with acute schizophrenia were randomly assigned to the group treated with Paliperidone release tablets(32 cases) or Olanzapine(34 cases). The initial dosage of paliperidone release tablets was 6 mg/d which could be adjusted 9 mg/d or 3 mg/d according to the situation of the patients and their tolerance. The average usage was (6.25±2.75)mg/d. To the olanzapine group,the initial dosage was 5 mg/d,and increased to 10 mg/d within one week. And then effects of the two groups were compared. Results Paliperidone release tablets got the efficacy rapidly. Olanzapine was better than Paliperidone release tablets in treating anxiety,depression,lacking of energy and behavior disorders. There were not serious adverse reactions in the duration of treatment. The advantage of Paliperidone release tablets wsd less weight gain. The advantage of Olanzapine was less lactation and menstrual disorder. Conclusion The treatment of Paliperidone release tablets and Olanzapine in acute schizophrenia is effective,with few side effects and safe..关键词
帕利哌酮/奥氮平/精神分裂症Key words
paliperidone release tablets/ olanzapine/ schizophrenia引用本文复制引用
苏华龙,符巍,李大齐,李清均,陈俊杉..帕利哌酮和奥氮平治疗精神分裂症急性期的对照研究[J].重庆医学,2011,40(27):2751-2753,3.
