摘要
Abstract
Objective To investigate the influencing factors of the carotid intima medial thickness ( IMT ) and whether long-term atorastatin treatment would ameliorate IMT in newly diagnosed type 2 diabetic patients complicated with carotid atherosclerosis. Methods One hundred and sixteen cases of newly diagnosed type 2 diabetic patients with carotid atheroclerosis were divided randomly into 2 groups of atorvastatin treatment and conventional treatment group. All patients were followed up 1 year. The levels of body mass index( BMI ), blood pressure, lipids, hemoglobin Alc( HbAlc ), fasting blood glucose ( FBG ), 2 hour postpradial glucose ( 2hPG ),matrix meralloproteinases-9 ( MMP-9 ) and IMT were measured before and after treatment. Results ( 1 ) After 1 year treatment, the levels of IMT and serum MMP-9 in atorvastatin group were significantly decreased than those of conventional treatment group( P ＜ 0.05 ). ( 2 ) In multivariate regression, the △IMT was significantly associated with age, the change of TC and MMP-9 after treatment( β= 0. 008、0. 051,0. 092 respectively, P ＜ 0.05 ). Conclusion The IMT appears to be closely related to the age, TC and MMP-9 in the patients with type 2 DM, furthermore, the long-term atrovastatin treatment could ameliorate the IMT in type 2 DM which may be associated with the decreasing of MMP-9 and lipids.关键词
阿托伐他汀/颈动脉粥样硬化/基质金属蛋白酶-9/糖尿病,2型Key words
Atorvastatin/ Carotid atherosclerosis/ Matrix meralloproteinases-9/Diabetes mellitus,type 2
