疑难病杂志2011，Vol.10Issue(10)：759-761,3.DOI:10.3969/j.issn.1671-6450.2011.10.017
血管内皮生长因子-C在卵巢上皮癌血清中的表达及其与侵袭和淋巴结转移的关系
The relationship of the expression and lymph node metastasis of serum vascular endothelial growth factor-C in epithelial ovarian carcinoma
摘要
Abstract
Objective To investigate the serum expression of vascular endothelial growth factor-C ( VEGF-C ), and detect relationship between the invasion and lymph node metastasis in epithelial ovarian carcinoma. Methods Fifty two patients with epithelial ovarian carcinoma were divided into positive lymph node metastasis sub-group( n = 29 )and negative lymph node metastasis sub-group( n =23 ),according to pathology results. The other 11 patients with ovarian cyst were enrolled as control group. The level of VEGF-C was analyzed with enzyme linked immunosorbent assay( ELISA )method. The relationship between the level of the VEGF-C and lymph node metastasis in epithelial ovarian carcinoma was analyzed. Results The serum level of VEGF-C in epithelial ovarian carcinoma was obviously higher than that of in the ovarian cyst group( P ＜ 0. 05 ). The Ⅲ ～ Ⅳ stage was much higher than those of the Ⅰ ～ Ⅱ stage( P ＜ 0. 05 ), and the Ⅲ grade sub-group was higher than those of the Ⅰ ～ Ⅱ sub-group( P ＜ 0. 05 ). The positive lymph node metastasis sub-group was higher than that of in the negative sub-group( P ＜0.05 ). Conclusion The level of the serum VEGF-C was closely correlated to invasion, pathology differentiation and lymph node metastasis in epithelial ovarian carcinoma.关键词
血管内皮生长因子-C/卵巢上皮癌/淋巴结转移/侵袭Key words
Vascular endothelial growth factor-C/Epithelial ovarian carcinoma/ Lymph node metastasis/ Invasion引用本文复制引用
尹磊浩,刘彦,冯秋霞..血管内皮生长因子-C在卵巢上皮癌血清中的表达及其与侵袭和淋巴结转移的关系[J].疑难病杂志,2011,10(10):759-761,3.
