疑难病杂志2011，Vol.10Issue(10)：762-764,封3,4.DOI:10.3969/j.issn.1671-6450.2011.10.019
转录调节因子-1在喉癌组织中的表达及其临床意义
Expression of E26 transformation-specific-1 in laryngeal carcinoma tissue and its clinical significance
刘春丽 1张圣林 1梁君伟 1石新华 1杨春悦 2胡俊兰3
作者信息
- 1. 067000,承德医学院附属医院耳鼻喉头颈外科
- 2. 067000,河北省承德市双桥区,教育系统卫生保健所
- 3. 050011,石家庄,河北医科大学第四医院耳鼻咽喉头颈外科
- 折叠
摘要
Abstract
Objective To investigate the expression of E26 transformation-specific-l( Ets-1 ) in laryngeal carcinoma and evaluate its role in carcinogenesis and progression of laryngeal carcinoma. Methods By immunohistochemistry ( SP ) method, expression of Ets-1 were tested in 34 cases of laryngeal carcinoma and para-carcinoma tissue specimens, 15 cases of vocal cord polyps. Then analyzed the immunohistochemical results semi quantitatively by using the pathological image analysis software. Results The quantitative and qualitative analysis of expression of Ets-1 protein in laryngeal carcinoma tissues was obviously higher than that in para-carcinoma and vocal cord polyps respectively( P ＜ 0.05 ). There was no significant differences of expression of Ets-1 between para-carcinoma and vocal cord polyps( P ＞0. 05 ). There was no significant difference a-mong the expression of Ets-1 protein, patients gender and age, tumor size and clinical classification( P ＞0. 05 ), but there are significant difference among the expression of Ets-1 protein and pathological grade, clinical stage and lymph nodes metasta-sis( P ＜0.01 ) . Conclusion Over-expression of Ets-1 was observed in laryngeal carcinoma. The high expression of Ets-1 may play an important role in the progression and lymph node metastasis of laryngeal carcinoma.关键词
喉癌/转录调节因子-1/免疫组化Key words
Laryngeal carcinoma/ E26 transformation specific-1/Immunohistochemistry引用本文复制引用
刘春丽,张圣林,梁君伟,石新华,杨春悦,胡俊兰..转录调节因子-1在喉癌组织中的表达及其临床意义[J].疑难病杂志,2011,10(10):762-764,封3,4.
