医药导报2011，Vol.30Issue(9)：1133-1136,4.DOI:10.3870/yydb.2011.09.004
连芪消渴胶囊对糖尿病肾病模型大鼠晚期糖基化终末产物与氧化应激损伤的影响
Effect of Lianqixiaoke Capsules on AGEs and Oxidative Stress Injury of Diabetic Nephropathy Rats
摘要
Abstract
Objective To investigate the effects and mechanism oflianqixiaoke capsules( LXC) on advanced glycation end-produc1a( AGEs) and the oxidative stress injury in kidneys of STZ-induced diabetic rats. Methods The Wistar rate were randanly divided into 6 groups, which were the control group fed with chow food, the other groups given with high fatdiets. After 4 weeks, the rats except the control were intraperitoneally injected with strep tozotocin ( STZ)30 mg·kg-1 . The diabetic rats were treated with LXC at high, middle and low doses, metfom in and vehicle, respectively Eightweeks later, the blood glucose, U-ALB, SOD, MDA, AGEs, TGF-β1 and TNF-α were measured And the kidney was removed for patiological analysis Results In the LXC group, FBG was( 18. 67 ±2. 52 ) mmol· L-1, MDA was( 1. 78 ±0. 39) nmol·g-1 , U-mALB was (41. 84 ± 8.23) μg· L-1,AGEs was(116.91±19.96) ng· mL-1, TGF-β1 was(33. 22±9. 94) ng· mL-1, TNF-α was(54. 01±17. 55) pg· mL-1, all of which were declined and SOD was( 190.11 ±15. 88) U·mg-1 , which was elevated. The function and pathological changes in kidney were significantly improved compared to those in the control group, especially for the high dose of LXC (P＜ 0.05). Conclusion The model of diabetic nephropathy in diabetic rate is successfully setup by feeding fatdiet and injecting low dose of STZ in rate LXC decreases AGEs and relieves diabetic kidney injuiy, the mechanisn of which could be associated with inhibiting production of AGEs, lowering oxidative stress and inflammatory factors.关键词
连芪消渴胶囊/糖尿病/晚期糖基化终末产物/氧化应激Key words
Lianqixiaoke capsules/ Diabetics/ Advanced glycation end-producte/ Oxidative stress分类
医药卫生引用本文复制引用
陈红艳,温航远,耿淼,王建华,黄正明,杨新波..连芪消渴胶囊对糖尿病肾病模型大鼠晚期糖基化终末产物与氧化应激损伤的影响[J].医药导报,2011,30(9):1133-1136,4.基金项目
解放军总医院新药研究开发基金资助项目(基金编号:NDR0713) （基金编号:NDR0713）
