中国组织工程研究与临床康复2011，Vol.15Issue(27)：5039-5043,5.DOI:10.3969/j.issn.1673-8225.2011.27.022
外周血间充质干细胞移植心肌梗死兔新生血管及心功能的变化
Effect of peripheral blood mesenchymal stem cells transplantation on neovascularization and cardiac function of myocardial infarction rabbits
刘志江 1石蓓 1赵然尊 1沈长银 1王冬梅 1王正龙1
作者信息
- 1. 遵义医学院第一附属医院心内科,贵州省遵义市563003
- 折叠
摘要
Abstract
BACKGROUND: Both Drug treatment and percutaneous coronary intervention cannot repair the necrotic myocardium following myocardial infarction.OBJECTIVE: To investigate the effect of peripheral blood mesenchymal st em cells (MSCs) transplantation on the neovascularization and cardiac function following myocardial infarction in rabbits.METHODS: Thirty-six New Zealand rabbits were divided into MSCs transplantation group (n=12), control group (n=12) and sham operation group (n=12). Rabbits models of acute myocardial infarction were established in the former two groups.RESULTS AND CONCLUSION: Flow cytometry demonstrated that most MSCs expressed CD44, very few cells expressed CD34 and CD45 at 4 weeks after cell transplantation. Transplanted MSCs could survive in infarcted myocardium. Left ventricular ejection fraction and left ventricular fractional shortening of the MSCs transplantation group were higher significantly than those of the control group (P ＜ 0.01). Left ventricular end-systolic diameter and end-diastolic diameter were lower significantly in the MSCs transplantation group than the control group (P ＜ 0.01). Myocardial fibrosis and myocardial infarct size were lower significantly in the MSCs transplantation group than the control group (P ＜ 0.01). Capillary density was increased significantly in the MSCs transplantation group compared with the control group (P ＜ 0.01). Peripheral blood MSCs transplantation increases new capillary density in infarcted myocardium and improves cardiac function.关键词
间充质干细胞/心肌梗死/外周血/细胞移植/兔分类
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刘志江,石蓓,赵然尊,沈长银,王冬梅,王正龙..外周血间充质干细胞移植心肌梗死兔新生血管及心功能的变化[J].中国组织工程研究与临床康复,2011,15(27):5039-5043,5.
