摘要
Abstract
BACKGROUND: Changes in skeletal muscle metabolic enzyme and free radical are related to different exercise modes and intensities.OBJECTIVE: To observe the changes in skeletal muscle metabolic enzyme and free radical in rats undergoing endurance exercise with gradually increased exercise intensities.METHODS: Healthy male Sprague-Dawley rats were randomly divided into a quiet control and an exercise group. Rats in the exercise group were subjected to 8 weeks of endurance exercise with gradually increased exercise intensities. After endurance exercise, skeletal muscle sample was taken to determine creatine kinase, lactic acid dehydrogenase, glutamic oxalacetic transaminase, glutamic-pyruvic transaminase, total antioxidase, hydrogen peroxidase and glutathione peroxidase activities as well as malondialdehyde level.RESULTS AND CONCLUSION: In the exercise group, creatine kinase, lactic acid dehydrogenase, glutamic oxalacetic transaminase, and glutamic-pyruvic transaminase activity as well as malondialdehyde levels were significantly greater (P ＜ 0.01 or P ＜ 0.05), and total antioxidase, hydrogen peroxidase, and glutathione peroxidase activities were significantly lower (P ＜ 0.05),compared with the quiet control group. Results showed that 8 weeks of endurance exercise with gradually increased exercise intensities can damage skeletal muscle to some extent, indicating that decreased activity of antioxidase is associated with increased activity of metabolic enzyme.关键词
耐力训练/骨骼肌/代谢酶/自由基/相关性分类
基础医学
