中国组织工程研究与临床康复2011，Vol.15Issue(30)：5556-5560,5.DOI:10.3969/j.issn.1673-8225.2011.30.012
桥接组合式金属内固定植入系统对犬骨折愈合的影响
Effects of bridge combined fixation system on healing of fractures in dogs
摘要
Abstract
BACKGROUND: In recent years, studies concerning internal fixation mainly emphasize on reducing stress-shielding effect and damage to blood supply.OBJECTIVE: To investigate the influence and mechanism of bridge combined fixation system (BCFs) on fracture healing.METHODS: Bilateral tibia of 20 adult dogs were osteotomized in the middle and fixed with BCFs (experimental group) on left or right side at random, another side fixed with plate (control group). Five animals in each group were sacrificed at 4, 8, 12, 16 weeks after operation and observed with pathological examination, X-ray examination, and light microscopy.RESULTS AND CONCLUSION: In the control group, fracture splitting, loose steel plate and steel fracture were found separately in one case at 3 weeks. While in the experimental group, flexu ral deformation was found in one case at 5 weeks. Callus could be observed with X-ray in the experimental group at 8 weeks, which was earlier than the control group. The X-ray grade of the experimental group were higher than that of the control group every period, and there were significant difference at 16 weeks (P ＜0 .05). Light microscopy showed that the quantity and quality of fibroblast, capillary vessel and callus of the experimental group were better than those of the control group. The hematoxylin-eosin stained grade of experimental group were higher than control gro up every period, there were prominent difference at 8 and 16 weeks (P ＜ 0.05). BCFs not only reduce the breakage of vessels near fracture part, but also afford firm and dynamic fixation for fracture fragment, which enhances healing and bone reconstruction.关键词
骨折固定/内固定器/骨折愈合/犬/动物实验分类
医药卫生引用本文复制引用
熊鹰,陆继鹏,李群辉,赵烽,张武..桥接组合式金属内固定植入系统对犬骨折愈合的影响[J].中国组织工程研究与临床康复,2011,15(30):5556-5560,5.基金项目
云南省教育厅科学研究基金资助项目(08C0113). （08C0113）
