重庆医学2011，Vol.40Issue(26)：2620-2621,2624,后插1,4.DOI:10.3969/j.issn.1671-8348.2011.26.008
KISS-1和MMP-9在51例鼻咽鳞状细胞癌中的表达和临床意义
Study on expression and clinical significance of KISS-1 and MMP-9 with 51 cases of nasopharyngeal squamous cell carcinoma
唐立滨 1宋旭东2
作者信息
- 1. 河北省唐山市人民医院耳鼻咽喉科,063001
- 2. 华北煤炭医学院病理科,河北唐山,063000
- 折叠
摘要
Abstract
Objective To study the significance of tumor inhibitive gene KISS-1 and matrix metalloproteinase9 in the nasopharyngeal carcinoma cancer and their relationship.Methods 51 cases of nasopharyngeal carcinoma and 30 cases of chronic thinitis were collected.Expression of KISS-1 protein and MMP-9 protein were examined by SP immunohistochemistry assays.The positive expression rates of KISS-1 and MMP-9 in the nasopharyngeal carcinoma tissue and in the chronic thinitis tissue were detected and were analyzed.Results The positive expression rate of KISS-1 protein in the chronic thinitis tissue(96.7％ ) was obviously higher than that in the nasopharyngeal carcinoma tissue(47.1％).The positive expression rate of MMP-9 protein in the nasopharyngeal carcinoma tissue(86.3％)was obviously higher than that of the chronic thinitis tissue(40.0％).The positive expression rate of MMP9 protein was obviously high in the nasopharyngeal carcinoma tissue, reversely of KISS-1 protein.It had negative relationship between the expression of KISS-1 protein and MMP-9 protein.Conclusion The abnormal expression of KISS-1 protein and MMP9 protein were correlated with invasion and metastasis of the nasopharyngeal carcinoma and may be important prognostic index for judging the clinical prognosis.At the same time,the detection of expression of those protein may be used for guiding clinical examine and treatment efficiently and promptly.关键词
基质金属蛋白酶9/鼻咽肿瘤/免疫组织化学/KISS-1Key words
matrix metalloproteinase9 / nasopharyngeal neoplasms / immunohistochemistry / KISS-1引用本文复制引用
唐立滨,宋旭东..KISS-1和MMP-9在51例鼻咽鳞状细胞癌中的表达和临床意义[J].重庆医学,2011,40(26):2620-2621,2624,后插1,4.
