国际医学放射学杂志2011，Vol.34Issue(5)：413-417,5.DOI:10.3784/j.issn.1674-1897.2011.05.10502
3.0T质子磁共振波谱在鉴别诊断胰腺癌和胰腺炎中的初步应用
Preliminary application of 3.0 T proton MR Spectroscopy in differential diagnosis of pancreatic cancer and pancreatitis
摘要
Abstract
Objective To ohserve H-MRS appearance of acute pancreatitis. chronic pancreatitis and pancreatic cancer,and to analyze the changes in metabolites. Methods Pancreas spectroscopies of 45 subjects were acquired hy single-voxel PRESS sequence on 3.0 T MR scanner. The subjects were divided into three groups, i.e., acute edematous pancreatitis (n=15), chronic pancreas (n.=10), and pancreatic cancer (n=20). Visibilities of metaholite were compared between pancreatitis and pancreatic cancer group. The ratio of cholesterol and the olefinic region of fatty acids (Chol+ Unsat) peak height to lipid (Lip) peak height (Chol+Unsat/Lip) was calculated in each group. One-way ANOVA with post hoc comparisons was performed among the three groups. Results There were three major resonance peaks in the spectra, Lip, Chol+Unsat, and choline. There was no significant difference in the visible rate of choline (x2=0.104. P=0.748) hetween pancreatitis and pancreatic cancer group. The mean value of' Chol+Unsat/Lip was 0.179+0.056 for acute pancreatitis, 0.274 +0.099 for chronic pancreatitis, 0.325±0.187 for pancreatic cancer, and they were statistically dif'ferent among the three groups (F=5.011, P=0.011). Furthermore, statistically significant difference in Chol+Unsat/Lip was observed between acute pancreatitis group and chronic pancreatitis group or pancreatic cancer group (both P＜0.05),but not hetween chronic pancreatitis and pancreatic cancer group (P=0.712). Conclusion Chol+Unsat/Lip may be helpful in differentiating acute panceatitis from chronic pancreatitis and pancreatic cancer.关键词
胰腺癌/慢性胰腺炎/急性胰腺炎/磁共振波谱成像/定量分析Key words
Pancreatic cancer/ Chronic pancreatitis/ Acute pancreatitis/ Magnetic resonance spectroscopy/Quantitative analysis引用本文复制引用
苏天昊,申皓,靳二虎,梁宇霆,张洁,邓力刚,贺文..3.0T质子磁共振波谱在鉴别诊断胰腺癌和胰腺炎中的初步应用[J].国际医学放射学杂志,2011,34(5):413-417,5.基金项目
首都医学发展科研基金(2007-3103),北京市科技计划(Z080507030808027) （2007-3103）
