中国病理生理杂志2011，Vol.27Issue(8)：1549-1551,3.DOI:10.3969/j.issn.1000-4718.2011.08.017
索拉非尼治疗肝移植术后肝癌复发的疗效与肿瘤组织Ki-67表达及微血管密度的关系
Relationship of Ki-67 expression, microvessel density and therapeutic effect of sorafenib on patients with tumor recurrence after liver transplantation
阚和平 1谭永法 1周杰1
作者信息
- 1. 南方医科大学南方医院肝胆外科,广东,广州,510515
- 折叠
摘要
Abstract
AIM: To study the therapeutic effect of sorafenib on patients with tumor recurrence after liver transplantation and its relation with the expression of Ki - 67 and microvessel density( MVD ).METHODS: Thirty patients with tumor recurrence after liver transplantation were treated with sorafenib.The therapeutic effect of sorafenib was observed.The expression of Ki - 67 and CD34 in the tissue samples of liver cancer were examined by immunohistochemistry.The MVD was also calculated according to the expression of CD34.RESULTS: In 30 patients treated with sorafenib, none of them achieved complete response ( CR ), 13 achieved partial response ( PR ), 8 had stable disease ( SD ), and 9 had progressive disease ( PD ).The therapeutic effect of sorafenib was associated significantly with Ki - 67 expression.The mean counts of MVD were 356.45 ± 156.13 in PR patients, and 99.39 ±49.88 in PD patients.A significant difference of MVD between PR and PD patients was observed.CONCLUSION: There is a better therapeutic effect of sorafenib in treating tumor recurrence after liver transplantation in the patients with Ki - 67 - positive expression and high MVD.关键词
索拉非尼/肝移植/肝肿廇/蛋白质Ki-67/抗原,CD34/微血管密度Key words
Sorafenib/ Liver transplantation/ Liver neoplasms/ Protein Ki -67/ Antigens,CD34/ Microvessel density分类
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阚和平,谭永法,周杰..索拉非尼治疗肝移植术后肝癌复发的疗效与肿瘤组织Ki-67表达及微血管密度的关系[J].中国病理生理杂志,2011,27(8):1549-1551,3.
