中国病理生理杂志2011，Vol.27Issue(8)：1647-1651,5.DOI:10.3969/j.issn.1000-4718.2011.08.037
ClC-3氯通道蛋白磷酸化及其功能的研究进展
Progress in ClC-3 chloride channel phosphorylation and functions
摘要
Abstract
ClC - 3 channel is one of voltage - gated chloride channels for chloride ion transmembrane, and participates in a variety of physiological and pathological processes, such as cell volume regulation, proliferation, migration, apoptosis, organic release and acidification of synaptic vesicle. The ClC -3 channel is controlled by many factors, including phosphorylation and dephosphorylation, to regulate the opening and closing. PKA( protein kinase A ), PKB, PKC and calcium calmodulin kinase Ⅱ are the key kinases in cell signal transduction pathway, which take part in the processes of ClC - 3 channel phosphorylation and regulate their functions. The study of ClC - 3 phosphorylation and functions are helpful to understand the importance of ClC - 3 in physiological and pathological processes and are premise to exploit the channel drugs for clinical therapy.关键词
ClC-3氯通道/磷酸化/信号转导通路Key words
ClC -3 chloride channel/ Phosphorylation/ Signal transduction pathway分类
生物科学引用本文复制引用
柏志全,李华荣,张海峰,朱林燕,王立伟,陈丽新..ClC-3氯通道蛋白磷酸化及其功能的研究进展[J].中国病理生理杂志,2011,27(8):1647-1651,5.基金项目
国家自然科学基金资助项目(No.30871267 （）
No.30870567 （）
No.30771106) （）
