中国病理生理杂志2011，Vol.27Issue(8)：1652-1656,5.DOI:10.3969/j.issn.1000-4718.2011.08.038
自噬在创伤性脑损伤中的作用
Effect of autophagy in traumatic brain injury
洪远 1郭松雪 1张建民1
作者信息
- 1. 浙江大学医学院附属第二医院神经外科,浙江,杭州,310009
- 折叠
摘要
Abstract
Autophagy is a metabolic process of eukaryotic cells.When lacking of nutrient and energy, the cells obtain biosynthetic materials by degrading the organelles and recycling the proteins to maintain homeostasis.Traumatic brain injury ( TBI) is a common kind of mechanic injury, usually with a poor outcome.Accumulated evidence indicates that the activity of autophagy increases after TBI.However, its implication for nervous tissue is still controversy.On one hand, autophagy exerts a protective effect on the neural cells.On the other hand, autophagy can also induce cell death exacerbating neural injury.This review focuses on the processes of autophagy and its roles in TBI, which may provide some novel therapeutic strategies.关键词
自噬/脑损伤/脑创伤Key words
Autophagy/ Brain injury/ Brain trauma分类
医药卫生引用本文复制引用
洪远,郭松雪,张建民..自噬在创伤性脑损伤中的作用[J].中国病理生理杂志,2011,27(8):1652-1656,5.
