中国临床保健杂志2011，Vol.14Issue(4)：404-405,后插4,3.DOI:10.3969/J.issn.1672-6790.2011.04.025
尼古丁对雄性小鼠睾丸中一氧化氮含量的影响
The effects of nitric oxide contributes to the nicotine-induced reproductive injury in male mice
乔彦1
作者信息
- 1. 解放军总参谋部警卫局卫生保健处,北京,100017
- 折叠
摘要
Abstract
Objective To study the contribution of nitric oxide(NO) to nicotine-induced reproductive injury in male mice.Methods 24 males Ku-Ming mice with eight weeks old were randomly divided into normal saline group,nicotine treated group(subcutaneous injection with nicotine 4.286mg · kg-1 · d-1 )for 8 weeks.The number and motility of epididymis sperm,the concentration of testosterone in testis and serum,the level of nitric oxide and NO synthase in testis were detected.Results Compared with normal saline group, the number and motility of.sperm decreased, and so did the concentration of testosterone in testis and serum in nicotine-treated group( P ＜ 0.05).Whereas,the concentration of NO and the expression of inducible NO synthuse increased in nicotine-treated group( P ＜ 0.05).Conclusion The augmentation of nitric oxide level may contribute to the nicotine-induced reproductive injury in male mice.关键词
生殖毒性/精子计数/尼古丁/一氧化氮/一氧化氮合酶/睾丸/小鼠Key words
Preconception injuries/ Sperm count/ Nicotine/ Nitric oxide/ Nitric oxide synthase/ Testis/ Mice分类
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乔彦..尼古丁对雄性小鼠睾丸中一氧化氮含量的影响[J].中国临床保健杂志,2011,14(4):404-405,后插4,3.
