基础医学与临床2011，Vol.31Issue(9)：980-983,4.
大鼠实验性蛛网膜下腔出血后脑内HSP72表达增加
Overexpression of HSP72 in cortex and hippocampus after experimental subarachnoid hemorrhage in rats
摘要
Abstract
Objective To assess the expression of HSP72 in cortex and hippocampus after experimental subarachnoid hemorrhage in rats.Methods Thirty-six wistar rats were randomly divided into three groups: sham operation,single intracisternal blood injection and double intracisternal blood injection.The expression of HSP72 in hippocampus and cerebral cortex was detected by immunohistochemistry and Westernblot technique.Results HSP72 expression was detected in intracisternal blood injection group by immunohistochemistry.Semiquantitative analysis of HSP72 electrophoretic bands indicated more expression in hippocampus and cerebral cortex in both injection groups compared with the sham group(SI: 0.63 ±0.17, 0.62 ±0.25; DI: 0.81 ±0.25, 0.83 ±0.34; P ＜0.05).Conclusion Subarachnoid hemorrhage produced by single and double intracisternal autogenious blood injection can cause HSP72 overexpression in hippocampus and cerebral cortex.关键词
蛛网膜下腔出血/脑血管痉挛/HSP72Key words
subarachnoid hemorrhage/ cerebral vasospasm/ HSP72分类
生物科学引用本文复制引用
范议方,韩如泉..大鼠实验性蛛网膜下腔出血后脑内HSP72表达增加[J].基础医学与临床,2011,31(9):980-983,4.基金项目
北京市科委科技新星资助项目(2007B74),教育部留学回国人员科研启动基金 （2007B74）
