中国组织工程研究与临床康复2011，Vol.15Issue(30)：5569-5572,4.DOI:10.3969/j.issn.1673-8225.2011.30.015
18FDG-PET术前评估骨与软组织肿瘤治疗效果的Meta分析
Meta analysis of 18F-deoxyglucose-positron emission tomography value in evaluation of response to therapy for primary bone and soft tissue sarcomas
姬涛 1朱赛楠 2郭卫 1汤小东 1唐顺1
作者信息
- 1. 北京大学人民医院骨与软组织肿瘤治疗中心,北京市,100044
- 2. 北京大学第一医院医学统计室,北京市,100034
- 折叠
摘要
Abstract
BACKGROUND: 18 F-deoxyglucose-positron emission tomography (18FDG-PET) can be used for bone and soft tissue malignant tumor identification, lesion location, degree of malignancy evaluation, biopsy site identification, effect and prognostic assessment.OBJECTIVE: To assess the value of 18FDG-PET in the evaluation of preoperative therapy response of bone and soft tissue sarcomas by systematic review and meta-analysis.METHODS: Databases of PubMed, Embase, Cochrane, CN KI, WanFang and VIP databases were searched for articles about PET application in diagnosis and treatment of bone and soft tissue malignant tumor.RESULTS AND CONCLUSION : Nine non-randomized controlled clinical studies which met the inclusion criteria were included for Meta analysis. Qualitative analysis found recommendation grade B in three studies and C in seven studies. No bias was found in the nine studies. Pooled sensitivity and specificity of cut point 0.5 (SUV2/SUV1) for the prediction of tumor necrosis ≥ 90％ were 0.82 (95％ confidence interval, 0.72 -0.89) and 0.61 (95％ confidence interval, 0.49 -0.71) respectively. The summary receiver operating characteristic curve (SROC) was 6.17 with 95％ confidence interval of 2.84 -13.39. Our results indicate that the SUVmax ratio before and after preoperative treatment can predict therapy response with compared high sensitivity, however lack of specificity. Evaluation of preoperative therapy should be determined with combination of 18FDG-PET and others.关键词
软组织肉瘤/骨肿瘤/FDG-PET/诊断价值/Meta分析分类
基础医学引用本文复制引用
姬涛,朱赛楠,郭卫,汤小东,唐顺..18FDG-PET术前评估骨与软组织肿瘤治疗效果的Meta分析[J].中国组织工程研究与临床康复,2011,15(30):5569-5572,4.
