中国组织工程研究与临床康复2011，Vol.15Issue(27)：5011-5015,5.DOI:10.3969/j.issn.1673-8225.2011.27.016
骨髓单个核细胞移植对心肌基质细胞衍生因子1-CXCR4轴的影响
Influence of autologous bone marrow mononuclear cells transplantation on SDF-1-CXCR4
张云强 1徐爱国 1齐向前1
作者信息
- 1. 天津医科大学心血管临床学院、泰达国际心血管病医院,天津市,300457
- 折叠
摘要
Abstract
BACKGROUND: Recently, the SDF-1-CXCR4 mRNA expression and the effect after stem cell transplantation have obtained more attention.OBJECTIVE: To observe the changes of SDF-1 mRNA and CXCR4 mRNA expression in the myocardium after bone marrow mononuclear cells (BM-MNCs) transplantation.METHODS: Sixteen mongrel dogs were randomly divided into the graft group and the control group. Each of dog was implanted a permanent pacemaker for rapid right ventricular pacing for 3 to 4 weeks. CM -DiI 1abled BM-MNCs or saline were transplanted into the myocardium via epicardium injection.RESULTS AND CONCLUSION: After 3-4 weeks of rapid pacing, the cardiac function of the dogs in both two groups significantly decreased in hemodynamic and in ultrasound parameters. The mRNA levels of SDF-1 and CXCR4 were higher in the graft group than those i n the control group (P ＜ 0.01). Autologous BM-MNCs transplantation improves the mRNA level of SDF-1 and CXCR4.关键词
快速右室起搏/骨髓单个核细胞/基质细胞衍生因子1/CXCR4/mRNA 表达分类
基础医学引用本文复制引用
张云强,徐爱国,齐向前..骨髓单个核细胞移植对心肌基质细胞衍生因子1-CXCR4轴的影响[J].中国组织工程研究与临床康复,2011,15(27):5011-5015,5.
