中国组织工程研究与临床康复2011，Vol.15Issue(27)：5063-5067,5.DOI:10.3969/j.issn.1673-8225.2011.27.027
软骨损伤后基质细胞衍生因子1的表达
Expression of stromal cell-derived factor-1 after articular cartilage injury
摘要
Abstract
BACKGROUND: Studies have demonstrated that stromal cell-derived factor-1 (SDF-1) can influence the migration and aggregation of bone marrow mesenchymal stem cells (BMSCs).OBJECTIVE: To observe the expression of SDF-1 at lesion regions at different time after cartilage injury and to investigate the correlation between SDF-1 expression and BMSCs migration.METHODS: Rabbits models of articular cartilage injury were established. Focal osteochondral lesions were collected 2, 5, 7, 10, 14 and 28 days after injury. The influence of SDF-1 expression on the migration of BMSCs and chondrocytes was observed.RESULTS AND CONCLUSION: SDF-1 expression was significantly increased and peaked at the seventh day (P ＜ 0.05).BMSCs migrated toward articular cartilage injury tissue, while they were significantly inhibited by the inhibitor of CXCL4. SDF-1 expression increases in the early phase after articular cartilage injury, and plays an important role in chemoattracting MSCs to injured lesions.关键词
基质细胞衍生因子1/骨髓间充质干细胞/CXC趋化因子受体4/软骨损伤/组织工程分类
基础医学引用本文复制引用
陆定贵,韦庆军,李桥川,韦积华,肖仕辉,李伟岸..软骨损伤后基质细胞衍生因子1的表达[J].中国组织工程研究与临床康复,2011,15(27):5063-5067,5.基金项目
课题受广西留学回国人员科学基金(305696)资助. （305696）
