中国组织工程研究与临床康复2011，Vol.15Issue(28)：5210-5212,3.DOI:10.3969/j.issn.1673-8225.2011.28.020
髋部骨折后下肢深静脉血栓形成家兔模型的建立
Establishment of rabbit models of lower limb deep venous thrombosis after hip fracture
摘要
Abstract
BACKGROUND: At present, many methods for inducing lower limb venous thrombosis lack of unified standards.OBJECTIVE: To establish rabbit models of lower limb venous thrombosis after hip facture METHODS: Hip fracture was induced in rabbits by impacting the root of left leg by a dropping object from a height of 28 cm. The right leg was not impacted and served as the control side. After 4 weeks, the iliac and femoral veins of the lower limbs were selected for color Doppler ultrasonography and blood coagulation examination. RESULTS AND CONCLUSION: Color Doppler ultrasonography showed that there was a thrombosis area with a length of (124±37) mm in the lower limb deep veins. No lower limb deep venous thrombosis was found in the control side. Thrombosis rate was 81.8％ and death rate was 9.1％. These findings suggest that rabbit models of lower limb deep venous thrombosis after hip fracture could be successfully established, and the method is simple and feasible.关键词
深静脉血栓形成/肺栓塞/髋/骨折/动物模型/组织构建分类
医药卫生引用本文复制引用
张英,贾丙申,周建强,谭海涛,王晟,付昆,孟志斌..髋部骨折后下肢深静脉血栓形成家兔模型的建立[J].中国组织工程研究与临床康复,2011,15(28):5210-5212,3.基金项目
课题受海南省自然科学基金项目(809046)资助,课题名称:中西医结合药物预防家兔髋部骨折后下肢深静脉血栓形成的实验研究. （809046）
