中国当代儿科杂志2011，Vol.13Issue(8)：638-643,6.
不同剂量丙种球蛋白治疗川崎病的疗效的Meta分析
Treatment of Kawasaki disease by different doses of immunoglobulin:a Mata analysis of therapeutic effects
摘要
Abstract
Objective To assess the therapeutic effects and safety of different doses of immunoglobulin in the treatment of Kawasaki disease. Methods The papers related to the treatment of Kawasaki disease were electronically searched in the databases of PubMed, EMBASE, Cochrane Library, CNKI, VIP and Wanfang. Randomized clinical trials (RCT) on the treatment of Kawasaki disease with different doses of immunoglobulin were included and assessed for quality. A Mata analysis was performed by RevMan 5.0. Results Twenty-eight RCTs involved 2596 cases were included.The results of Meta analysis showed that there were no significant differences in the incidences of coronary artery injuries at various phases, adverse effects and fever disappearance time between the immunoglobulin treatment groups at the doses of 1 g/( kg · d) for 1-2 days and 2 g/( kg · d) for single use. The fever disappearance time in the immunoglobulin treatment group at the dose of 1 g/( kg · d) for 1-2 days was significantly shorter than that in the immunoglobulin treatment group at the dose of 400 mg/(kg · d) for 4-5 days, but there were no significant differences in the incidences of coronary artery injuries at the acute phase and 6 months after treatment and adverse effects between the two groups. The incidence of coronary artery injuries at the acute phase and 6 months was lower and the fever disappearance time was shorter in the immunoglobulin treatment group at the dose of 2 g/( kg · d) for single use than those in the immunoglobulin treatment group at the dose of 400 mg/( kg · d) for 4-5 days, but there were no significant differences in the incidences of coronary artery injuries at the subacute phase and 12 months after treatment and adverse effects between the two groups. Conclusions There are similar therapeutic effects for Kawasaki disease between the immunoglobulin treatment groups at the doses of 1 g/( kg · d) for 1-2 days and 2 g/( kg · d) for single use. The fever disappearance time in the two groups is shorter than that in the treatment group at the dose of 400 mg/( kg · d) for 4-5 days.关键词
丙种球蛋白/川崎病/Meta分析/儿童Key words
Immunoglobulin/ Kawasaki disease/ Meta analysis/ Child分类
医药卫生引用本文复制引用
陈婧,马彬,林丽星,薛一鸣..不同剂量丙种球蛋白治疗川崎病的疗效的Meta分析[J].中国当代儿科杂志,2011,13(8):638-643,6.基金项目
兰州大学循证医学中心"循证医学创新项目"(2010LDEBM-A). （2010LDEBM-A）
