病毒性心肌炎小鼠心肌基质金属蛋白酶-9的动态变化及意义OA北大核心CSCDCSTPCD
Expression of matrix metalloproteinase-9 in myocardium of mice with viral myocarditis
目的 探讨基质金属蛋白酶-9(MMP-9)在病毒性心肌炎(VMC)小鼠发病过程中的动态变化及意义.方法 以柯萨奇病毒B3感染BALB/C小鼠建立VMC模型,腹腔注射0.1 mL不含病毒的培养液的小鼠作为对照组.造模后7d、14d、21d、28d取心肌组织作石蜡切片,行苏木精-伊红和Masson染色观察病理改变,免疫组化(SABC法)检测心肌MMP-9及Ⅰ、Ⅲ型胶原表达.结果 模型组MMP-9于7d可见表达,14d达高峰(P<0.05),各时…查看全部>>
Objective To investigate the dynamic changes of expression of matrix metalloproteinases-9 in myocardium of mice with viral myocarditis (VMC) and its significance in the pathogenesis of viral myocarditis.Methods VMC model was prepared by an injection of CVB3 in BALB/C mice.The mice receiving an injection of culture solution without virus were used as the control group.Cardiac tissues were obtained 7, 14, 21 and 28 days after injection and made into paraffin s…查看全部>>
杨敏;陈淳媛;蔡姿丽;陈柏林;成亮;李辉
中南大学湘雅三医院儿科,湖南,长沙,410013中南大学湘雅三医院儿科,湖南,长沙,410013中南大学湘雅三医院儿科,湖南,长沙,410013中南大学湘雅医院消化内科,湖南,长沙,410008中南大学湘雅三医院儿科,湖南,长沙,410013中南大学湘雅三医院儿科,湖南,长沙,410013
医药卫生
病毒性心肌炎基质金属蛋白酶-9Ⅰ型胶原Ⅲ型胶原小鼠
Viral myocarditis Matrix metalloproteinases-9 Type Ⅰ collagen Type Ⅲ collagen Mice
《中国当代儿科杂志》 2011 (8)
669-673,5
湖南省卫生厅科研基金(B2009-019)湖南省自然科学基金(09JJ5025).
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