中国组织工程研究与临床康复2011，Vol.15Issue(29)：5389-5392,4.DOI:10.3969/j.issn.1673-8225.2011.29.017
几丁糖对大鼠股动脉吻合口通畅率的影响
Chitosan effect on femoral artery anastomosis patency rate in rats
王亚峰 1袁正江 1赵爱娟 1张新营 1梁豪2
作者信息
- 1. 河南科技大学第一附属医院,显微外科,河南省洛阳市,471003
- 2. 河南科技大学第一附属医院,泌尿外科,河南省洛阳市,471003
- 折叠
摘要
Abstract
BACKGROUND: Chitosan can effectively prevent postoperative tissue adhesion. But in amputation, whether replantation surgery has effects on vascular anastomosis is less reported.OBJECTIVE: To study the medical effects of chitosan on adult rat femoral artery anastomosis patency rate. METHODS: Bilateral tra nsection of the femoral artery was performed in SD rats, left side as the experimental group, and contralateral (right) as the control group. Anatomosis of bilateral femoral artery was performed under a microscope, all the immediate arterial anastomosis patency rate was 100％, and the same person operated. One drop of chitosan was covered surrounding the anatomosis site in the experiment group. After 7, 14, 21, 28 days, anastomotic patency was observed as well as anastomotic diameter, with or without infecti on around the stoma, adhesions around the anastomosis, anastomotic coverage of endothelial cells (biopsy).RESULTS AND CONCLUSION: Preoperative and postoperative anastomotic diameter had no significant changes in the experimental group and control group without obvious infection around the stoma. The adhesion was slighter in the experimental group than in the control group. The overall anastomotic patency rate was 96％ in the experimental group, and 89％ in the control group. At various time periods after operation, endothelial cell coverage had no difference between the two groups. Chitosan does not affect the rat femoral artery anastomosis overall patency rate.关键词
几丁糖/股动脉/通畅率/大鼠/吻合分类
医药卫生引用本文复制引用
王亚峰,袁正江,赵爱娟,张新营,梁豪..几丁糖对大鼠股动脉吻合口通畅率的影响[J].中国组织工程研究与临床康复,2011,15(29):5389-5392,4.
