中国组织工程研究与临床康复2011，Vol.15Issue(29)：5493-5496,4.DOI:10.3969/j.issn.1673-8225.2011.29.043
高通量透析膜对维持性血液透析过程中溶质清除及皮肤瘙痒的作用
Effect of high-flux dialysis membrane on uremic pruritus and solute clearance of maintenance hemodialysis patients
毕会 1张敏 1尹彩兰 1龙刚1
作者信息
- 1. 天津市人民医院肾脏病科,天津市,300121
- 折叠
摘要
Abstract
BACKGROUND:How to effectively remove uremic toxins, reduce complications and improve the quality of life and long4errn prognosis in maintenance hemodialysis patients has been a hot spot.OBJECTIVE: To compare the effects of high-flux and low-flux polysulfone membrane dialyzers on uremic pruritus and solute remove.Thirty-eight maintenance hemodialysis patients with u remic pru ritus were randomly divided into high-flux group and low-flux group. High-flux dialyzer FX60 and low-flux dialyzer F6 were used respectively in the two groups. The dialysis was performed three times a week, once for 4 hours. All the patients were follow-up for one year. Blood urea nitrogen (BUN),creatinine, phosphate, β2 -microglobulin and parathyroid hormone (PTH) were tested, and solute clearance rate and Kt/V value were calculated. The degree of skin itch was evaluated by the visual analogue scale (VAS).RESULTS AND CONCLUSION: There was no significant difference between the two groups in the decrease of BUN and creatinine (P ＞ 0.05). But the decreases of phosphate and β2 -microglobulin in the high -flux group were higher than that in the low-flux group (P ＜ 0.05). And there was no difference in Kt/V value between the two groups (P ＞ 0.05). After one year, the decrease of PTH in the high-flux group was superior to that in the low-flux group (P ＜ 0.05), and compared to pretreatment, the skin itch was relieved in both groups (P ＜ 0.05), but the score in the high -flux group was better than that in the low-flux group (P ＜0.05). It is indicated that the high-flux dialysis can not only clear the micromolecule toxins, but also increase the clearance of large-middle molecule toxins, and can significantly relieve uremic pruritus.关键词
高通量透析/血液透析膜/溶质/皮肤瘙痒/β2微球蛋白分类
基础医学引用本文复制引用
毕会,张敏,尹彩兰,龙刚..高通量透析膜对维持性血液透析过程中溶质清除及皮肤瘙痒的作用[J].中国组织工程研究与临床康复,2011,15(29):5493-5496,4.
