中国组织工程研究与临床康复2011，Vol.15Issue(34)：6289-6291,3.DOI:10.3969/j.issn.1673-8225.2011.34.005
镓盐对骨质疏松症大鼠骨组织中羟基磷灰石及胶原含量的影响
Effects of gallium nitrate on the content of hydroxyapatite and collagen in osseous tissues of rats with osteoporosis
摘要
Abstract
BACKGROUND: In recent years, it is discovered that gallium nitrate can decrease bone conversion.OBJECTIVE: To observe the effects of gallium nitrate on the content of hydroxyapatite and collagen in rats with osteoporosis.METHODS: The rats were divided into control group, osteoporosis group and gallium nitrate group. Osteoporosis rat modelswere made by cutting off the bilateral ovaries in the latter two groups. The rats in the gallium nitrate therapy group were treatedwith 1 mg/kg gallium nitrate, three times a week through abdominal cavity; those in the control and osteoporosis groups wereadministrated with normal saline. The rats in the three groups had free access to water and standard food. All the contents ofhydroxypatite and collagen in osseous tissue were determined and analyzed.RESULTS AND CONCLUSION: The content of hydroxyaptite between the osteoporosis group and normal control group wasdifferent significantly (P ＜ 0.05); there were no significant differences among gallium nitrate therapy group, control group andosteoporosis group (P ＞ 0.05), but the content of hydroxyaptite in the gallium nitrate group had increasing trend compared withthat in the normal group. The level of collagen in osteoporosis group was obviously lower than that in normal control group andgallium nitrate therapy group (P ＜ 0.05). When osteoporosis happened, the level of collagen in osteoporosis rats decreased andthe content of hydroxyapatite was in the trend of increasing, and gallium nitrate could inhibit the process.关键词
硝酸镓/骨质疏松症/羟基磷灰石/胶原/大鼠分类
基础医学引用本文复制引用
庞炜,康乐,付友兰,王倩云,贾红兵..镓盐对骨质疏松症大鼠骨组织中羟基磷灰石及胶原含量的影响[J].中国组织工程研究与临床康复,2011,15(34):6289-6291,3.基金项目
兰州军区医药卫生科研基金项目(LXH20-11) （LXH20-11）
