中国组织工程研究与临床康复2011，Vol.15Issue(31)：5835-5838,4.DOI:10.3969/j.issn.1673-8225.2011.31.032
滇南小耳猪人工瓣膜置换模型的建立
Establishment of Diannan small-ear pig models of artificial valve replacement
摘要
Abstract
BACKGROUND: The pig 's heart is considered most anatomically similar to the human heart, and therefore is an ideal model for studying cardiovascular diseases.OBJECTIVE: To establish Diannan small-ear pig models of mitral valve replacement and investigate the feasibility of model establishment by cardiac ultrasonog raphy.METHODS: Ten adult pigs underwent mitral valve replacement via the left atrial appendage under cardiopulmonary bypass through three replacement models. At 2 weeks after replacement, changes in cardiac structure and function were analyzed using cardiac ultrasonography.RESULTS AND CONCLUSION: One pig died for cardiopulmonary arrest during anesthesia induction. The remaining nine pigs survived after surgery. Cardiac ultrasonography showed that at 2 weeks after transplantation, there was no significant difference in cardiac structure and function compared with prior to transplantation, artificial valve showed good hemodynamics and histocompatibility in the pig's body, and before and after transplantation, pig's cardiac structure and function were stable.关键词
猪/人工瓣膜/动物模型/二尖瓣置换/心脏超声分类
基础医学引用本文复制引用
黄栋,张桂敏,杨鸿生,孙毅..滇南小耳猪人工瓣膜置换模型的建立[J].中国组织工程研究与临床康复,2011,15(31):5835-5838,4.基金项目
国家自然科学基金资助项目(30860279),课题名称:瓣下结构对人工心瓣膜下游血流动力学影响的体内定量研究. （30860279）
