中国组织工程研究与临床康复2011，Vol.15Issue(34)：6335-6338,4.DOI:10.3969/j.issn.1673-8225.2011.34.016
医用镍钛形状记忆合金羟基磷灰石涂层的制备及其生物活性
Preparation and bioactivity of hydroxyapatite in medical NiTi-shaped memory alloy
摘要
Abstract
BACKGROUND: At present, many plasma spraying technology in titanium and its surface of alloys coated hydroxyapatite (HA)coatings, and composite materials were prepared. However, the HA coating usually desquamated during the period of coolingdue to the different expansion coefficient between HA and titanium alloy substrate.OBJECTIVE: To prepare dense, uniform coating of HA bioceramic on the surface of medical niti -shaped memory alloy, and toinvestigate the biocompatibility of NiTi/HA composite by animal experiment.METHODS: HA coatings on the surface of NiTi-shaped memory alloy were prepared via electrochemical deposition fromaqueous electrolytes containing calcium and phosphorus ions at low temperature and then treated with alkaline solution. Theeffects of technological parameter on the structure of coating were analyzed. The bioactivity of the composite materials wasstudied by animal implantation experiment, and compared with NiTi/HA and Ca3 (PO3)2?2H2O hybrid coating composite materials,medical NiTi-shaped memory alloy, and medical Ti alloy.RESULTS AND CONCLUSION: The electrochemical-deposition alkali treatment is suitable to prepare bioactive ceramic coatingof HA on the surface of NiTi-shaped memory alloy. Deposition voltage and temperature have strong influence on the coatingstructure. There were varying degrees of hyperblastosis in the surrounding region after 4 kinds of materials implanted in animal.Chondrocyte and trabecular bone formation could be seen in periosteal tissue sections. Implant materials tissue coated with HAcoating had a mild reaction, the number of chondrocyte and trabecular bone was the largest in the corresponding histologicalsection and uniform distribution. The results showed that HA coating improved the bioactivity of medical niti -shaped memoryalloy.关键词
镍钛形状记忆合金/羟基磷灰石涂层/电化学沉积/生物活性/表面改性分类
医药卫生引用本文复制引用
尹燕,马宝玉,夏天东,夏亚一,达国祖..医用镍钛形状记忆合金羟基磷灰石涂层的制备及其生物活性[J].中国组织工程研究与临床康复,2011,15(34):6335-6338,4.基金项目
兰州理工大学博士基金项目. （）
