中国组织工程研究与临床康复2011，Vol.15Issue(34)：6364-6367,4.DOI:10.3969/j.issn.1673-8225.2011.34.023
多孔丝素材料组织相容性的初步研究
A preliminary study on the histocompatibility of silk fibroin
摘要
Abstract
BACKGROUND: As one kind of naturally occurring polymers, silk fi broin has been widely used in tissue engeering research,which can be made into different forms for application. Scientists find many difficulties in histocompatibility study of silk fibroin,because it is made of protein and biodegradable. And there are few reports on the study on histocompatibility of silk fibroin.OBJECTIVE: To perform a preliminary in vivo study on the histocompatibility of silk fibroin.METHODS: Porous silk fibroin scaffolds were buried into the subcutaneous part of the back of SD rats. At 4, 6, 8 weeks afteroperation, general observation and histological examination were performed.RESULTS AND CONCLUSION: The wounds healed up well after operation. Only thin connective tissue wrap was found on silkfibroin scaffold. Macrophages were observed in tissue section, and fibroblasts and capillary vessels could grow into the porespaces. We found the border of the scaffolds break down at 8 weeks postoperatively, while the inside part remained as it was.Porous silk fibroin scaffold shows good histocytes attachment and has good histocompatibility. More study should be made on themechanism and product of degradation in vivo.关键词
丝素蛋白/多孔支架/组织工程/组织相容性/体内实验分类
基础医学引用本文复制引用
陆艳,赵霞,邵正中,曹正兵,蔡丽慧..多孔丝素材料组织相容性的初步研究[J].中国组织工程研究与临床康复,2011,15(34):6364-6367,4.基金项目
国家自然科学基金面上项目(30772400) （30772400）
上海医学院青年骨干科研启动基金(09L-12)(B类)(部分资助). （09L-12）
