摘要
Abstract
BACKGROUND: There is no injected drug dosage form listing because of solubility and hemolysis problem of ibuprofen.OBJECTIVE: To put ferrofluid into magnetic solid lipid nanoparticles (MSLN) so as to prepare ibuprofen-MSLN.METHODS: The optimal formulation was obtained by orthogonal experiment design, based on the encapsulate efficiency (EE％).Fe3O4 magnetic fluid was perpared with co-precipitation method as magnetic materials. Ibuprofen-MSLN was finally acquired withthe method of emulsification dispersion-ultrasound. The appearance, the size distribution, Zeta potential, saturationmagnetization, EE％ and in vitro release characteristics were observed.RESULTS AND CONCLUSION: The optimal formulation was ibuprofen 0.05 g, F-68 0.2 g, Tween 800.05 g, lecithin 0.1 g,glyceryl monostearate 0.05 g, ferrofluid 2.5 mL. The ibuprofen-MSLN was uniformly spherical; the average size and Zeta potentialwere (122±16) nm and (-13.3±6.94) mV, respectively; the EE％ of ibuprofen and ferroso-ferric oxide were 84.15％ and 83.19％,respectivley; the release of ibuprofen-MSLN was complete in the given media in 36 hours. Ibuprofen-MSLN prepeared by thiscondition and technology is consistent with the demand of nano-preparations.关键词
布洛芬/磁性固体脂质纳米粒/制备/制剂学性质/药物控释系统及其载体材料分类
基础医学
