临床神经病学杂志2011，Vol.24Issue(4)：244-247,4.
血管紧张素转换酶基因插入/缺失多态性与原发性高血压合并缺血性脑卒中关系的Meta分析
Mere-analysis of relationship between angiotension-converting enzyme gene insertion/deletion polymorphism and essential hypertension complicated with ischemic stroke
摘要
Abstract
Objective To research the relationship between angiotension-converting enzyme (ACE) gene insertion/deletion(I/D) polymorphism and essential hypertension( EH ) complicated with ischemic stroke(IS) ( EH+IS). Methods The case-control studies of ACE gene I/D polymorphism and EH+IS in 4 famous Chinese technological periodical full-text database and Medline from January 1997 to October 2010 were searched. The literatures were selected by inclusion and exclusion criteria and were Meta-analyzed by RevMan 5.0 software. Results The 12 ease-control studies were included, in which patients with EH + IS were 1068 cases and patients with EH were 1225 cases. Meta-analysis results showed that the risk of occurrence of IS in the population of EH who carried D allele and DD genotype was significantly higher than who carried I allele and non-DD genotype respectively, and the pooled OR were 1.50 ( 95 ％ CI: 1.33 - 1.70 ) and I. 83 ( 95 ％ CI: 1.32 - 2.55 ) respectively. The risk of occurrence of IS in the population of EH who carried II genotype was significantly lower than who carried non-II genotype, and the pooled OR was O. 63 ( 95％ CI: O. 53 - O. 76 ). Conclusions ACE gene I/D polymorphism is significantly associated with the occurrence of IS in the population of EH. D allele and DD genotype are risk factors of IS.关键词
血管紧张素转换酶/原发性高血压/缺血性脑卒中/基因多态性/Meta分析Key words
angiotension-converting enzyme/ essential Hypertension/ ischemic stroke/ gene polymorphism/ Meta-analysis分类
医药卫生引用本文复制引用
吴晓梅,朱博,时景璞..血管紧张素转换酶基因插入/缺失多态性与原发性高血压合并缺血性脑卒中关系的Meta分析[J].临床神经病学杂志,2011,24(4):244-247,4.基金项目
国家自然科学基金资助项目(30671796) （30671796）
