临床神经病学杂志2011，Vol.24Issue(4)：248-250,3.
血管紧张素Ⅱ2型受体基因A1675G多态性与脑梗死的关系
Relationship between angiotensin Ⅱ 2 receptor gene A1675G polymorphisms and cerebral infarction
摘要
Abstract
Objective To approach the relationship between the angiotensin Ⅱ 2 receptor (AT2R) gene A1675G polymorphism and cerebral infarction(CI).Methods In the case-control study, the AT2R gene A1675G mononucleotide polymorphism was tested with nested allele-specific primer (NASP)-PCR in 180 CI patients and 130 healthy coutrols ( normal control group).The distribution of genotype and allele frequencies in CI group and normal control group was analyzed and compared between the two groups, and the genetic factor was analyzed by Logistic regression analysis.Results The AT2R gene 1675 site G allele frequency in CI group (29.2％) was significantly lower than that in the normal control group (51.8％)( P＜ 0.05 ).G allele frequency in male control subgroup (48.8％ ) was significantly lower than that in the female control subgroup (57.6％), but there was no statistical difference.G allele frequency in male CI subgroup(21.4％ ) was significantly lower than that in female CI subgroup (43.6％) and male control subgroup(48.8％ ) (all P ＜0.05).G allele frequency in female CI subgroup was lower than the female control subgroup, the difference had statistically significance ( P ＜ 0.05 ).The Logistic regression analysis showed that AT2R gene G allele could decrease the rate of the CI ( OR =0.38, P ＜0.05 ).Conclusions AT2R gene AI675G polymorphism has protective effect on CI, even better for male.关键词
脑梗死/血管紧张素Ⅱ2型受体/基因多态性/性别Key words
cerebral infarction/ AT2R/ gene polymorphism/ gender分类
医药卫生引用本文复制引用
和姬苓,孙洪英,杨国安,张利荣,程景丽,张佳,宋瑞琦..血管紧张素Ⅱ2型受体基因A1675G多态性与脑梗死的关系[J].临床神经病学杂志,2011,24(4):248-250,3.基金项目
内蒙古自治区自然科学基金项目(20080404MS1103) （20080404MS1103）
