临床神经病学杂志2011，Vol.24Issue(4)：251-253,3.
血管紧张素Ⅱ受体-1基因A1166C多态性与脑梗死的关系
Relationship between polymorphism of angiotensin Ⅱ trpe 1 receptor gene A1166C and cerebral infarction
摘要
Abstract
Objective To investigate the relationship between polymorphism of angiotensin Ⅱ type 1 receptor (AT1R) gene A1166C and cerebral infarction.Methods Frequencies of AT1R gene A1166C genotype and allele were sequenced in 120 cerebral infarction patienta (CI group) and 150 normal controls (NC group) by PCR and restriction fragment length polymorphism technique, and the result were compared.Results The distributions of genotype frequency Al 166C in CI group and NC group had group representation through Hardy-Weinberg analysis.Frequency of AC genotype and C allele in CI group were 35.0％, 17.5％ respectively; in NC group were 16.0％,8.0％ respectively.There were significant differences between the two groups ( all P ＜ 0.05 ).Conclusion The AC genotype and C allele of AT1R A1166C may be the risk factor of cerebral infarction.关键词
脑梗死/血管紧张素Ⅱ受体-1基因/多态性Key words
cerebral infarction/ angiotensin Ⅱ trpe 1 receptor gene/ polymorphism分类
医药卫生引用本文复制引用
柳四新,谭红,王家琪..血管紧张素Ⅱ受体-1基因A1166C多态性与脑梗死的关系[J].临床神经病学杂志,2011,24(4):251-253,3.
